Supplements Alongside GLP-1 Medication: What People Take and How to Track Them

Last reviewed October 2026. This article summarises published guidance and explains how to keep records. It does not recommend any supplement or amount. Whether you need a supplement, and which one, is a decision for your prescriber or a registered dietitian, ideally informed by your own blood tests.

Why the question comes up

GLP-1 medicines such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) reduce appetite. Eating less is the point, but less food can also mean less of the vitamins, minerals and protein that food provides. So people on these medicines often ask: should I be taking something?

The most useful source on this is a joint advisory published in 2025 by the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association and The Obesity Society, titled Nutritional priorities to support GLP-1 therapy for obesity.

What the 2025 joint advisory says

Paraphrasing its main points on nutrients, with direct quotes where precision matters:

• Nutrients of concern. The advisory says "nutrients of concern include iron, calcium, magnesium, zinc, and vitamins A, D, E, K, B1, B12, and C." It notes intake can become inadequate at lower calorie levels.
• Supplements are individual, not routine. It says "dietary supplements can be proactively considered for at-risk nutrients," with doses tailored to each person. It names vitamin D, calcium, B12 and a multivitamin-mineral tablet as candidates in that context.
• Assessment before and during. It suggests additional assessment or lab testing for people with higher baseline risk, such as a history of bariatric surgery, very low-calorie diets, celiac disease or previous deficiency, and recommends re-assessing nutrient levels during therapy.
• Protein and strength training. It calls sufficient dietary protein "a priority to help preserve muscle mass and bone density," and pairs it with resistance training, noting that protein alone is likely not enough.
• Fluids and fibre. It recommends adequate fluids and, for constipation, fluids and fibre from foods, increased gradually.

The takeaway is not "everyone on a GLP-1 should take X". It is "know which nutrients can run low, get assessed, and supplement where there is a reason to".

Supplements people commonly ask about

These are the categories that come up most often in conversations between patients and clinicians. Listing them here is not a recommendation.

Category	Why people ask	Question for your clinician
Multivitamin-mineral	Eating less overall	Do I need one, and which kind?
Vitamin D and calcium	Bone health during weight loss	Should my levels be checked first?
Vitamin B12	Named in the advisory; also relevant to some other medicines	Is a test worthwhile for me?
Iron	Named in the advisory	Is there a reason to check my iron?
Protein powder	Hard to reach protein needs with a small appetite	How much protein should I aim for?
Fibre	Constipation is a common side effect	Food first, or a supplement?
Electrolytes	Fluid loss with nausea, vomiting or diarrhoea	When would I need these?

Products marketed as "natural GLP-1" boosters deserve a separate note: they are dietary supplements, not GLP-1 medicines. The NIH Office of Dietary Supplements points out that US supplements are not approved by the FDA for safety and effectiveness before sale, and the FDA warns that some supplements interact with medicines. Check with your clinician before adding one.

What to record

Good records make the conversation with your clinician faster and more useful. For each supplement:

1. Exact name and strength from the Supplement Facts panel.
2. Why you started and who suggested it.
3. Start date, and stop date if you stop.
4. Time of day and meal timing, such as with breakfast.
5. Taken or skipped, day by day.

Alongside the supplements, keep the things that put them in context: your injection day and dose as prescribed, side effects such as nausea or constipation, weight trend, and the dates and results of any blood tests. Our guides to the GLP-1 side effects log, protein on GLP-1 and hair changes on GLP-1 cover those records in more detail.

Questions to bring to your next appointment

• Given my diet now, are there nutrients I am likely to be short on?
• Should any levels be checked, and when should they be re-checked?
• Do any of my current supplements interact with my other medicines?
• Should any supplement be taken at a different time from my other medicines?
• When should we review whether I still need it?

Tracking it in one place

The practical problem is that a weekly injection and daily supplements tend to live in different places: a GLP-1 tracker for the shot, a notes app or nothing for the pills. TrackPep, which we build, keeps both on one Today checklist. Add each supplement with the strength from its label, group it into a stack such as Morning, set it with or without food, and tick it off in one tap; your weekly injection, meals, water and weight sit in the same app. TrackPep records what you choose; it does not recommend supplements or amounts. See the supplement tracker and GLP-1 tracker pages.

Key takeaways

• There is no universal GLP-1 supplement list; a 2025 joint advisory frames supplements as individual decisions for at-risk nutrients.
• Iron, calcium, magnesium, zinc and several vitamins, including D and B12, are named as nutrients of concern.
• Get assessed, decide with your clinician, then record what you take, when, and why.
• Keep supplements and injections on one list so your records tell one story.