glp1
Tirzepatide tracker
Educational reference for Tirzepatide. Use it inside TrackPep to log doses, side effects, and rotation sites.
Half-life
120 h
Tmax
24 h
Category
glp1
Also known as: tirz, Mounjaro, Zepbound
Tirzepatide is a first-in-class dual GIP and GLP-1 receptor co-agonist developed by Eli Lilly. Unlike single-receptor agonists, tirzepatide activates both incretin pathways with an imbalanced bias toward GIP signalling, which is thought to contribute to its superior weight-loss and glycaemic efficacy in head-to-head trials versus semaglutide. Its half-life of approximately 120 hours supports once-weekly dosing. Tirzepatide is marketed as Mounjaro for type 2 diabetes and Zepbound for chronic weight management. Patients transitioning from other GLP-1 therapies may need dose titration and careful side-effect monitoring. Tracking injection site rotation, gastrointestinal tolerance, and weight trends over time helps optimise individual outcomes.
Mechanism
A dual GIP and GLP-1 receptor agonist. In research it engages both incretin pathways, which is associated with improved glycemic control and appetite regulation. A fatty-acid moiety supports albumin binding and a once-weekly dosing interval.
Research summary
Evaluated for type 2 diabetes in the SURPASS program and for obesity/weight management in the SURMOUNT program. Marketed as Mounjaro for diabetes and Zepbound for weight management.
Reported side effects
Gastrointestinal effects (nausea, diarrhea, decreased appetite, vomiting) are most frequently reported, generally during dose escalation. Prescribing information includes warnings such as thyroid C-cell tumor risk in rodents and pancreatitis. This is not a complete safety profile.
Educational summary of published research. Not dosing guidance or medical advice.
Sources
- SURMOUNT trials of tirzepatide (NEJM) · New England Journal of Medicine (2022)search PubMed/NEJM for SURMOUNT-1
- SURPASS program (tirzepatide in type 2 diabetes) · peer-reviewed clinical trial series (2021)search PubMed for SURPASS
- Mounjaro / Zepbound prescribing information · FDA prescribing information (2022)available via DailyMed / accessdata.fda.gov
References
- Tirzepatide PK in healthy subjectsDOI: 10.1002/cpdd.1099
- SURPASS-2 trial: tirzepatide vs semaglutideDOI: 10.1016/S0140-6736(21)01343-4
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