Half-life

2 h

Tmax

1 h

Category

peptide

Also known as: thymosin beta-4 fragment

TB-500 is a synthetic fragment of thymosin beta-4, a naturally occurring actin-sequestering protein involved in cytoskeletal organisation and cell migration. Preclinical studies have suggested roles in wound healing, angiogenesis, and anti-inflammatory signalling. Its plasma half-life is approximately 2 hours, which has led to variable dosing protocols in practice. TB-500 is often discussed alongside BPC-157 in peer protocols for soft-tissue recovery. However, controlled human trials are scarce, and its safety profile outside of research settings is not well characterised. Users who track TB-500 should document dosing frequency, injection sites, and subjective recovery outcomes.

Mechanism

A synthetic fragment related to thymosin beta-4. In preclinical work it is described as an actin-binding peptide implicated in cell migration and tissue-repair signaling; human mechanistic data are limited.

Research summary

Evidence is largely preclinical and drawn from thymosin beta-4 research. It is not FDA-approved for human therapeutic use, and controlled human clinical data are sparse. In July 2026 an FDA advisory committee (the Pharmacy Compounding Advisory Committee) voted to recommend this compound for the 503A bulk-compounding list. That recommendation is non-binding and is not FDA approval — it would still require formal rulemaking, and no approved clinical evidence of safety or efficacy exists.

Reported side effects

The human safety profile is not well established given the lack of controlled trials. Sourcing and purity are recurring quality concerns.

Educational summary of published research. Not dosing guidance or medical advice.

Sources

Thymosin beta-4 tissue-repair overview · peer-reviewed review article (2012)parent molecule literature; search PubMed for thymosin beta-4
Regulatory status note · FDA / regulatory guidance (2023)not an approved drug; verify current status

References

Thymosin beta-4 overviewDOI: 10.1196/annals.1415.021

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