Tirzepatide half-life calculator
See how Tirzepatide accumulates across repeated doses, where the level plateaus, and how long it takes to clear — modelled from published half-life estimates.
Tirzepatide has a half-life of roughly five days, so weekly doses accumulate for about four weeks before the level flattens out. Adjust the dose and interval to see that curve.
Estimates for education — not a clinical measurement.
The curve is a simple one-compartment model built on published population half-lives. It is not a plasma concentration, it does not account for your physiology, and it is not dosing advice.
Your schedule
Half-life: 5 d · Time to peak: 24 h
FDA prescribing information for Mounjaro/Zepbound: mean half-life ≈ 5 days (~120 h); Tmax 8–72 h.
Estimated amount in system
Relative active amount from your dose, summed across repeated doses. The dashed line is the steady-state average.
- Steady-state peak
- 7.13 mg
- Steady-state trough
- 3.16 mg
- Accumulation factor
- 1.61×
- Time to steady state
- 25 d
- Time to clear
- 25 d
- Peak to trough drop
- 56%
Estimates only. Values are relative amounts, not plasma concentrations.
Tirzepatide half-life and accumulation
Each dose of Tirzepatide decays exponentially: half is gone after one half-life, three quarters after two. Dose again before the previous dose has cleared and the remainders stack, which is why levels climb for the first few weeks of a protocol before flattening out. That plateau is steady state, and it arrives at roughly five half-lives. The same five-half-life rule describes clearance after the last dose.
FDA prescribing information for Mounjaro/Zepbound: mean half-life ≈ 5 days (~120 h); Tmax 8–72 h.
Tirzepatide half-life FAQ
- How long does Tirzepatide stay in your system?
- As a rule of thumb, about five half-lives after the last dose roughly 97% has been eliminated. Set your dose and interval above to see that figure for the schedule you are modelling.
- How long until Tirzepatide reaches steady state?
- About five half-lives of consistent dosing. Until then, levels are still climbing dose over dose even though nothing about the schedule has changed.
Try the general half-life calculator or browse all free tools.